Jump to navigation Jump to search This article is about the p21Cip1 protein. DNA polymerase accessory factor, and plays a regulatory role in S phase Programmed cell death ligand 1 expression in canine cancer replication and DNA damage repair.
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This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. However p21 may inhibit apoptosis and does not induce cell death on its own. Studies of p53 dependent cell cycle arrest in response to DNA damage identified p21 as the primary mediator of downstream cell cycle arrest. 53 but not those with mutant p53, moreover constitutive expression of p21 led to cell cycle arrest in a number of cell types.